منابع مشابه
Guiding neuronal cell migrations.
Neuronal migration is, along with axon guidance, one of the fundamental mechanisms underlying the wiring of the brain. As other organs, the nervous system has acquired the ability to grow both in size and complexity by using migration as a strategy to position cell types from different origins into specific coordinates, allowing for the generation of brain circuitries. Guidance of migrating neu...
متن کاملGuiding neuronal growth with light.
Control over neuronal growth is a fundamental objective in neuroscience, cell biology, developmental biology, biophysics, and biomedicine and is particularly important for the formation of neural circuits in vitro, as well as nerve regeneration in vivo [Zeck, G. & Fromherz, P. (2001) Proc. Natl. Acad. Sci. USA 98, 10457-10462]. We have shown experimentally that we can use weak optical forces to...
متن کاملGuiding neuronal development with in situ microfabrication.
We report the ability to modify microscopic 3D topographies within dissociated cultures, providing a means to alter the development of neurons as they extend neurites and establish interconnections. In this approach, multiphoton excitation is used to focally excite noncytotoxic photosensitizers that promote protein crosslinking, such as BSA, into matrices having feature sizes >/=250 nm. Barrier...
متن کاملMethods for neuronal guiding and synapse formation
HYPOTHESIS Light at certain wavelengths, can cross the cell, tissue sections and organ tissues for in-vitro studies, but can also be used for in-vivo studies. The ability to guide the growth of neural extensions was proven by laser. Synapses produced with laser have the instability as main disadvantage, in the absence of high densities of neurons. The main mechanism of synapse formation is the ...
متن کاملGenetic control of neuronal migrations in human cortical development.
The early steps in corticogenesis are decisive for the correct unfolding of neurogenesis, neuronal migration and differentiation under tight genetic control. In this monograph, we outline the main events in human preplate formation, the gradual transformation of the preplate into the cortical plate, and the establishment of the transient compartments of the foetal cortical wall. The main neuron...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2010
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a001834